The Theatre of a Two-headed Calf was born in 1999 in New Orleans. Since then, co-founders Brooke O'Harra and Brendan Connelly have created work at La MaMa, E.T.C., PS 122, The Perishable Theater, The Ontological-Hysteric Theater and the HERE Arts Center, among other great venues. They received an Obie Award in 2008, as did company member Heidi Schreck for her performance in Drum of the Waves of Horikawa.

The Two-headed Calf's work is about layering, a careful consideration of all the formal elements of Theater, from lights and set, to words, music and movement. Their work comes out of long rehearsal periods, conceived from the outset as intense collaborations between director, actor, designer, choreographer and composer. The result in a dense, playful conversation that tries to engage the audience viscerally and mentally.

Their house band is the new music ensemble Yarn/Wire.

In 2008, the Two-headed Calf added a department: The Dyke Division of the Two-headed Calf, which runs the ongoing lesbian soap opera, Room for Cream.

Both Brooke and Brendan have been participants in the TCG/NEA Career Development Program.